
Frequently Asked Questions
Can TMG interact with other supplements or medications?
TMG works in the methylation cycle, which also involves choline, folate, vitamin B12, and SAMe. If you're using high-dose niacin (B₃), combining TMG can reduce methyl depletion.
Speak with your doctor if you’re taking B-vitamin, methylation-affecting medications, or have metabolic conditions (e.g., MTHFR mutation).
What's the difference between betaine and betaine hydrochloride (HCl)?
Betaine (TMG) is used to support heart, liver, and cell function.
Betaine HCl adds stomach acid and is used to aid digestion, not interchangeable with TMG.
When is the best time to take it?
Split doses (morning + evening) support consistent methylation. Gym‑goers may take one dose pre‑workout for performance benefits.
Who should avoid it?
Adults with kidney disease or specific metabolic conditions should consult a healthcare professional. Not recommended for pregnant or breastfeeding women without advice.
Is it safe long‑term?
Generally considered safe at daily doses under 3–4 g. Effects on cholesterol should be monitored in long‑term high‑dose use.